Blood-forming stem cells are able to count and store remembrances of the number of times that they divide, findings which could have got major implications for disease research, scientists at the Icahn School of Medicine at Mount Sinai have found. Their particular study appeared in the November 17 issue of Cell .
Hematopoietic stem cells (HSCs) are stem cells that live in bone marrow and are responsible for maintaining the continuous creation of blood throughout life. HSCs have been used medically for decades to treat various blood-borne illnesses ranging from leukemia in order to severe combined immunodeficiency syndrome. However , a major barrier in order to treatment is the limited availability of stem cells. Clinicians plus researchers have worked to expand stem cell numbers, yet have been largely unsuccessful at facilitating reproduction of these tissues. This research provides clues as to why these efforts never have succeeded — because these cells count and retain the memory of their divisions, which control their potential for more reproduction.
According to the researchers, the study found that will slow cycling cells contained all of the long-term HSC exercise among the aging cells in the bone marrow. The data gathered further shows that age-related changes to the HSCs, including HSC expansion, are dependent on the cells knowing how many times they have separated.
“What this essentially means is that these types of important stem cells remember how many times they have separated, and those memories control how they will self-renew in the future, inch said Kateri Moore, DVM, Associate Professor of Cellular, Developmental and Regenerative Biology at the Icahn School associated with Medicine at Mount Sinai. “This knowledge may be able to assist us find the key to expanding the numbers of these types of cells for therapeutic and research use. ”
Both Dr . Moore and the lead author Jeffrey Bernitz, a PhD candidate at the Icahn School associated with Medicine at Mount Sinai, hope that the results of this particular study will provide additional clues that will help us achieve come cell expansion in the future.
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