A team of scientists reports that it has found a better way to purify liver cells made from induced pluripotent stem cells (iPSCs). The study (“Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes”), published in Stem Cell Reports, is expected to aid work on liver disease for the National Heart, Lung, and Blood Institute (NHLBI)’s $80 million Next Generation Genetic Association Studies (Next Gen) Program. 

 

The University of Minnesota, the Medical College of Wisconsin, and  Medical University of South Carolina (MUSC) were involved in the the study.

This new methodology could facilitate progress toward an important clinical goal: the treatment of patients with disease-causing mutations in their livers by transplant of unmutated liver cells derived from their own stem cells. Previous attempts to generate liver-like cells from stem