Researchers at Case Western Reserve University School of Medication have successfully grown stem cells from children with a destructive neurological disease to help explain how different genetic experience can cause common symptoms.  

The work sheds light about how certain brain disorders develop, and provides a framework intended for developing and testing new therapeutics. Medications that show up promising when exposed to the new cells could be precisely customized to individual patients based on their genetic background.

Within the new study (” Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes”),   published in  The American Journal of Individual Genetics, investigators used stem cells in their laboratory in order to simultaneously model different genetic scenarios that underlie neurologic disease. They identified individual and shared defects within the cells that could inform treatment efforts.

The tram created induced pluripotent stem cells from…