A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, safer, and more cost-effective strategy for generating progenitor-like cells from adult cells. Researchers converted adult mouse respiratory tract cells called Club cells into large, pure populations of induced progenitor-like cells, which retained a residual memory of their parental cell lineage. Moreover, these cells showed potential as a cell replacement therapy in mice with cystic fibrosis.