Researchers from Stanford University, the Buck Institute, Columbia University, and the USCF School of Medicine, report that target of rapamycin (TOR), a nutrient-sensing pathway critical to the aging process, drives the loss of adult stem cells. Treating mice with the TOR inhibitor rapamycin prevented this loss and could reverse age-related loss of stem cells in mouse trachea, say the scientists who published their study (“ mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance ”) in  Cell Stem Cell . 

“The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged animals. Here, we show that target of rapamycin (TOR) signaling is a key regulator of SC loss during repeated regenerative episodes. In response to regenerative stimuli, SCs in the intestinal epithelium of the fly and in …