The Neural Mother Cell Physiopathology Research Group of the particular University of Seville and the Seville Institute of Biomedicine (IBiS) have just published a scientific article within the review Cell Reports , in which they will show that mother cells from the adult carotid entire body can transform into blood vessels, as well as into neurons. The job has mainly been carried out by the post-doctoral researcher Valentina Annese, as a member of the group.
This particular discovery could have important repercussions on the advance in remedying of diseases as different as paediatric tumours and Parkinson’s. “We believe that the ability to produce blood vessels from neural comes cells could directly affect the growth of certain forms of tumours on the infant population, ” said the project’s main researcher, Ricardo Pardal.
The carotid body is a small structure of nerve tissue situated on the fork of the carotid artery. Its function is to behave as a chemoreceptor in the blood. It monitors oxygen stress in the blood and plays a role in the regulation of inhaling and exhaling.
The plasticity of adult mother tissue, or the somatic mother cells, to cross boundaries and also to differ in unrelated cell types has been a subject associated with debate in the last decade. The stem cells that come through the neural crest (NCSCs) show notable plasticity during their growth, but it is not known if adult NCSCs maintain this particular plasticity.
In this sense, “we describe how the adult stem cells from the carotid body taken from the particular neural crest (CBSCs) are capable of experiencing endothelial differentiation, and also their already described role in neurogenesis, contributing to each neurogenic and angiogenic processes that take place in the body organ during acclimation to hypoxia. In addition , the conversion associated with CBSCs into blood vessels is dependent on the hypoxia-inducible factor (HIF) and is sensitive to vascular cytokines released in hypoxia, such as erythropoietin. Our data highlights a notable physical plasticity in an adult population of stem cells particularly from tissue, and they could have an impact on the use of individuals cells for cellular therapy, ” Pardal added.
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