Compounds from grapes may kill colon cancer originate cells both in a petri dish and in mice, based on a team of researchers.
The compounds — resveratrol — which are found in grape skins and seeds, could also eventually lead to treatments to assist prevent colon cancer, said Jairam K. P. Vanamala, associate professor of food sciences, Penn State. Intestines cancer is the second leading cause of cancer-related deaths within the U. S., according to the American Cancer Society.
“The combination of resveratrol and grape seed extract is extremely effective at killing colon cancer cells, ” said Vanamala, who is also a faculty member at the Penn State Hershey Cancer Institute. “And what we’re learning is the mixture of these compounds is not toxic to healthy cells. inch
The researchers, who reported their results in a recent issue of BMC Contrasting and Alternative Medicine , suggest that the findings can pave the way for clinical testing of the compounds upon human colon cancer, which is the second most common cancer within women and the third in men. If successful, the substances could then be used in a pill to help prevent digestive tract cancer and lessen the recurrence of the disease within colon cancer survivors.
“We are especially interested in targeting stem cells because, according to cancer stem-cell theory, cancerous tumors are driven by cancer originate cells, ” said Vanamala. “Cancer stem cells are equipped for self-renewal, cellular differentiation and maintain their stem cell-like features even after invasion and metastasis. ”
Whenever taken separately in low doses, resveratrol and grape seed extract are not as effective against cancer stem-cell suppression as when they are combined together, according to the scientists.
The combined effect of grape seed draw out and resveratrol may offer clues as to why cultures having a plant-based diet tend to have lower colon cancer rates, mentioned Vanamala. These diets may naturally be providing a shotgun approach to cancer prevention by using a wide variety of beneficial compounds to multiple pathways that cancer stem cells use to endure.
“This also connects well with an use of plant diet that is structured so that the person is getting a little bit of various kinds of plants, of different parts of the plant and different colors of the put, ” said Vanamala. “This seems to be beneficial for not only marketing bacterial diversity, but also preventing chronic diseases and removing the colon cancer stem cells. ”
If successful in human trials, the compounds might be taken in low doses using currently available supplements for grape seed extract and resveratrol, which are also found in wines.
However , he added that there is still a lot more work to do to understand the mechanism behind the anti-cancer properties of the grape extract, as well as other colorful fruits and vegetables. More research would be aimed at finding specific anti-cancer compounds plus better understanding how those compounds work synergistically to create more efficient colon-cancer prevention and treatment strategies.
For your animal study, the researchers separated 52 mice along with colon cancer tumors into three groups, including the control group and groups that were fed either the particular grape compounds or sulindac, an anti-inflammatory drug, that was chosen because a previous study showed it significantly decreased the number of tumors in humans.
The occurrence of tumors was suppressed in the mice consuming the particular grape compounds alone by 50 percent, similar to the rate within the group consuming the diet with sulindac.
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