University of Birmingham researchers say they have used extracellular vesicles (EVs) to repair damaged tissues in a manner that simulates the body’s natural healing process. Their paper (“Annexin-Enriched Osteoblast-Derived Vesicles Act as an Extracellular Site of Mineral Nucleation within Developing Stem Cell Cultures”), published in  Scientific Reports , illustrates a novel method to bone regeneration—stimulating cells to produce vesicles that can then be delivered to facilitate tissue regeneration. 

“We sought to define the capacity of EVs derived from mineralising osteoblasts (MO-EVs) to induce mineralisation in mesenchymal stem cell (MSC) cultures and delineate the underlying biochemical mechanisms involved. Strikingly, we show that the addition of MO-EVs to MSC cultures significantly (P