Author: Stem Cells Daily

Mouse Pups Have Two (Biological) Mommies

Using embryonic stem cells and gene editing, healthy mice have been bred from two mothers for the first time. The bimaternal mice not only lived into adulthood, they successfully reproduced with male mice to produce healthy offspring. Mice were also produced from two fathers, but, did not live past a few days. The work was published recently in the journal  Cell Stem Cell in a paper titled, “ Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions ”. Co-senior author Qi Zhou, Ph.D. professor at the State Key Laboratory of Stem Cell and Reproductive Biology at the Chinese Academy of Sciences in Beijing, China says, We were interested in the question of why mammals can only undergo sexual reproduction. We have made several findings in the past by combining reproduction and regeneration, so we tried to find out whether more normal...

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Mouse pups with same-sex parents born in China using stem cells and gene editing

Researchers were able to produce healthy mice with two mothers that went on to have normal offspring of their own. Mice from two dads were also born but only survived for a couple of days. The work looks at what makes it so challenging for animals of the same sex to produce offspring and suggests that some of these barriers can be overcome using stem cells and targeted gene...

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