Author: Stem Cells Daily

Spare parts from small parts: Novel scaffolds to grow muscle

Australian biomedical engineers have successfully produced a 3D material that mimics nature to transform cells into muscle. The researchers have for the first time incorporated the natural processes of embryonic development to build a material that can more naturally communicate with stem cells for effective tissue repair. The breakthrough offers hope to people suffering from injuries where their muscles cannot repair themselves due to trauma or disease, and our rapidly aging population. Led by Dr Richard Williams from RMIT University, in Melbourne Australia, the researchers have combined lab-made peptides with natural proteins and polymers to create a 3D “hydrogel...

Read More

Lab-grown human cerebellar cells yield clues to autism

Increasing evidence has linked autism spectrum disorder (ASD) with dysfunction of the brain’s cerebellum, but the details have been unclear. In a new study, researchers used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD-like...

Read More

Oxford BioMedica, Bioverativ to Develop Lentiviral Vectors for Hemophilia Gene Therapy

Oxford BioMedica said today it will partner with Bioverativ to develop and manufacture lentiviral vectors designed to treat hemophilia, through a collaboration that could generate up to $105 million-plus for Oxford BioMedica. Bioverativ—which is being acquired by Sanofi for approximately $11.6 billion—has agreed to license Oxford BioMedica’s LentiVector® Enabled technology, as well as its industrial-scale manufacturing technology. LentiVector is a lentiviral-based gene delivery system designed to overcome safety and delivery challenges associated with earlier-generation vectors. According to Oxford BioMedica, the platform’s advantages include large therapeutic payloads (up to 9 kb), permanent modification of dividing and nondividing cells, and no pre-existing immunity The platform can also integrate genes into nondividing cells, including in the brain and retina, with the company citing long-term studies suggesting gene expression may be maintained indefinitely—offering the prospect of permanent therapeutic benefit following a single administration. LentiVector is also a research tool, with applications in transgenesis, stem cell manipulation, somatic disease models, target validation, and gene discovery. Oxford BioMedica CTO James Miskin, Ph.D., told GEN last year that Oxford BioMedica developed its vector manufacturing capacity to its current scale through £7.7 million ($10.8 million) in catalytic funding, which was provided partly as a grant and partly as a loan by the U.K. government’s Advanced Manufacturing Supply Chain Initiative (AMSCI). Bioverativ has agreed to pay Oxford BioMedica $5 million upfront, up to $100 million in payments tied...

Read More

Adult endothelial stem cells can make fully functional blood vessels

Stem cells are increasingly used to treat disorders caused by defective tissues. The repair of blood vessels by vascular endothelial stem cells (VESCs) is an attractive therapeutic option, but the existence of this type of stem cell has not been conclusively shown. Researchers identified a VESC that can regenerate blood vessels and treat a rare bleeding disorder. These VESCs have the potential to serve as a new cell-based therapy for blood vessel-related...

Read More

Our Facebook Page

Facebook By Weblizar Powered By Weblizar