Author: Stem Cells Daily

Using barcodes to trace cell development

There are various concepts about how blood cells develop. However, they are based almost exclusively on experiments that solely reflect snapshots. Scientists now present a novel technique that captures the process in a dynamic way. Using a ‘random generator,’ the researchers label hematopoietic stem cells with genetic barcodes that enable them to trace which cell types arise from the stem...

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How a nutrient, glutamine, can control gene programs in cells

Researchers show that an intracellular metabolite of glutamine, alpha-ketoglutarate, plays a role in regulating cellular differentiation programs by changing the DNA-binding patterns of the transcription factor CTCF and by altering genome interactions. As an added level of gene program control complexity, they have found that the genome’s context near the binding sites — such as epigenetic changes or altered genome topology — affects whether the binding turns on or turns off gene...

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How do broken bones heal?

This page was printed from: http://www.medicalnewstoday.com/articles/318961.php Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day. 2017 Healthline Media UK Ltd. All rights reserved. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare...

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Novel stem cell-derived model created of inflammatory neurological disorder

This page was printed from: https://www.medicalnewstoday.com/releases/318954.php Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day. 2017 Healthline Media UK Ltd. All rights reserved. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare...

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Stem Cell Injections Rejuvenate Aging Rat Hearts

Researchers at the Cedars-Sinai Heart Institute have shown that injecting cardiac stem cells from young rats into the hearts of old rats can help to reverse the natural cardiac aging process. Results from the studies, led by Eduardo Marbán, M.D., Ph.D., director of the Cedars-Sinai Heart Institute, suggest that similar treatments might one day be used to prevent age-related heart function decline and cardiovascular disease in humans. The Cedars-Sinai studies are reported in the European Heart Journal, in a paper entitled “Cardiac and Systemic Rejuvenation after Cardiosphere-Derived Cell Therapy in Senescent Rats.” As we get older the likelihood of developing cardiovascular disease increases. Cell senescence underpins the cardiac aging process, and this is characterized by the shortening of telomeres, the end caps on our chromosomes. Telomere shortening is associated with heart dysfunction and hypertrophy, impaired cardiomyocyte proliferation, interstitial fibrosis, and reduced regenerative capacity. Dr. Marbán’s team completed the world’s first human cardiac stem cell infusion back in 2009 as part of a Phase I trial in heart attack patients. In the latest animal studies, the researchers tested whether cardiosphere-derived cells (CDCs) from newborn rats could reverse or hold back aging in the hearts of old animals. CDCs are cardiac progenitor cells that can differentiate into the three primary cardiac cell types—cardiomyocytes, endothelial cells, and and smooth muscle cells. The researchers injected CDCs directly into the hearts of aged rats...

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