Author: Mira Swave MD

Mini Lungs Developed to Help Scientists Study Respiratory Diseases

Researchers at the Columbia University Medical Center have developed mini lungs or organoids in the laboratory to help study respiratory diseases. The 3-D structures closely mimic adult-sized lungs and have been created from pluripotent stem cells to serve as models of lung diseases in the laboratory. The findings were reported in Nature Cell Biology. Mini Lungs Developed to Help Scientists Study Respiratory Diseases The 3-D organoids contain the various types of cells found in human lungs and they resemble the full-sized organs in both look and function. These mini lungs, therefore, can be used to study human respiratory diseases,...

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Harvard Scientists Say Lab-Grown Stem Cells Must Be Screened

A team of researchers at the Harvard Stem Cell Institute, working in collaboration with investigators at the Broad Institute of MIT and Harvard, has identified the gene mutation that leads to uncontrolled cell division and tumor formation in some stem cell lines. The Harvard scientists say the findings suggest the need to screen lab-grown stem cells for such mutations. Cancer Risk with Stem Cell Therapy The research indicates that indiscriminate use of stem cell therapies could lead to an elevated risk of cancer in patients receiving stem cell transplants. The team identified acquired mutations in p53, a gene that...

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Gene Editing Technology May Help Fight Arthritis

Researchers have used gene-editing technology and stem cells modified for autonomous regenerative therapy (SMART) to help fight arthritis. Arthritis and many other chronic conditions are associated with inflammation. The idea is to replace arthritic cartilage in the affected joints with stem-cell-produced cartilage and a biological anti-inflammatory agent. New Research into Arthritis Therapy Investigators at the Washington University School of Medicine and the Shriners Hospitals for Children in St. Louis have collaborated with researchers from Cytex Therapeutics and Duke University in Durham, NC. Initially, the team took the skin cells of mouse tails and created stem cells from these in...

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Stem Cell Technologies Help Discover New Targets for Chlamydia Drugs

Researchers at the University of British Columbia and the Wellcome Trust Sanger Institute have collaborated to create a novel technique that will allow scientists to observe the interaction of chlamydia with the immune system in humans. Chlamydia Trachomatis: An Overview Chlamydia is a common sexually transmitted infection. More than 130 million people are infected with chlamydia each year. This so-called “silent disease” does not produce any early symptoms, but without treatment may lead to PID (pelvic inflammatory disease) and infertility. In 2016, the World Health Organization issued new guidelines for the treatment of chlamydia, keeping in mind the increasing...

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Stem Cells with Key Role in Knee Joint Repair Identified

Researchers at the University of Aberdeen in the United Kingdom have identified the stem cells that play a key role in repairing the knee joints. The findings of the team from the Center for Arthritis and Musculoskeletal Health were published in Nature Communications. Stem Cells with Key Role in Knee Joint Repair Identified The connective tissue surrounding the knee joint is known as the synovium. Conditions such as injury or arthritis are associated with an inflammation of this thin membrane, causing it to become thick with increased synovial fluid, leading to pain and swelling. The team has identified the...

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